Authors
Joseph R Winer, Kacie D Deters, Gabriel Kennedy, Meghan Jin, Andrea Goldstein-Piekarski, Kathleen L Poston, Elizabeth C Mormino
Publication date
2021/10/1
Journal
JAMA neurology
Volume
78
Issue
10
Pages
1187-1196
Publisher
American Medical Association
Description
Importance
Disrupted sleep is common in aging and is associated with cognition. Age-related changes to sleep are associated with multiple causes, including early Alzheimer disease pathology (amyloid β [Aβ]), depression, and cardiovascular disease.
Objective
To investigate the associations between self-reported sleep duration and brain Aβ burden as well as the demographic, cognitive, and lifestyle variables in adults with normal cognition.
Design, Setting, and Participants
This cross-sectional study obtained data from participants in the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Disease (A4) study, which is being conducted in 67 sites in the United States, Canada, Australia, and Japan. The sample for this analysis consisted of individuals aged 65 to 85 years who underwent an Aβ positron emission tomography (PET) scan, had complete apolipoprotein E (APOE) genotype data, and were identified as …
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Scholar articles
JR Winer, KD Deters, G Kennedy, M Jin… - JAMA neurology, 2021