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Environmental impact assessment of urbanization and road network analysis are more essential for city's health measurement. Road contraction due to high urbanization is more impactful for the ecology and traffic congestion-related phenomena. Remote sensing (RS) is a highly applied approach for analyzing the environmental and road cities network-related activities. Landsat 5 TM and 8 OLI/TIRS databased and recent time road network information were used and aimed for assessment of different cities (i.e., Baghdad “Iraq” and Los Vegas “United States”). The Land use and land cover (LULC) and road network are related to each other's due to the high urbanization and population pressure. Based on modeling results, built-up zones of the selected cities were increased by 249.84 km² (Baghdad) and 728.47 km² (Los Vegas) while barren land fluctuated 396.85 km² (Baghdad) and −712.58 km² (Los Vegas …