Authors
Angel Lanas, Luis A García-Rodríguez, Maria T Arroyo, Luis Bujanda, Fernando Gomollón, Montserrat Forné, Sofia Aleman, David Nicolas, Faust Feu, Antonio González-Pérez, Ana Borda, Manuel Castro, Maria Jose Poveda, Juan Arenas, Investigators of the Asociación Española de Gastroenterología (AEG
Publication date
2007/3/1
Journal
Official journal of the American College of Gastroenterology| ACG
Volume
102
Issue
3
Pages
507-515
Publisher
LWW
Description
OBJECTIVES
After the withdrawal of some cyclooxygenase-2 (COX-2) selective inhibitors, traditional nonsteroidal anti-inflammatory drug (NSAID) use has increased, but without additional prevention strategies against upper gastrointestinal (GI) complications in many cases. Here, we report the effect of antisecretory drugs and nitrates on the risk of upper GI peptic ulcer bleeding (UGIB) associated with nonselective NSAIDs, aspirin, antiplatelet agents, and anticoagulants.
METHODS
This case–control study matched 2,777 consecutive patients with UGIB (confirmed by endoscopy) with 5,532 controls (2: 1). Adjusted relative risks (RR) of UGIB are reported.
RESULTS
Proton pump inhibitors (PPIs)(RR 0.33, 95% confidence interval [CI] 0.27–0.39), H2-receptor antagonists (H2-RAs)(RR 0.65, 95% CI 0.50–0.85), and nitrates (RR 0.52, 95% CI 0.38–0.70) reduced UGIB risk. PPI use was associated with greater reductions …
Total citations
Scholar articles
A Lanas, LA García-Rodríguez, MT Arroyo, L Bujanda… - Official journal of the American College of …, 2007