Authors
Andrew M Demchuk, Dar Dowlatshahi, David Rodriguez-Luna, Carlos A Molina, Yolanda Silva Blas, Imanuel Dzialowski, Adam Kobayashi, Jean-Martin Boulanger, Cheemun Lum, Gord Gubitz, Vasantha Padma, Jayanta Roy, Carlos S Kase, Jayme Kosior, Rohit Bhatia, Sarah Tymchuk, Suresh Subramaniam, David J Gladstone, Michael D Hill, Richard I Aviv
Publication date
2012/4/1
Journal
The Lancet Neurology
Volume
11
Issue
4
Pages
307-314
Publisher
Elsevier
Description
Background
In patients with intracerebral haemorrhage (ICH), early haemorrhage expansion affects clinical outcome. Haemostatic treatment reduces haematoma expansion, but fails to improve clinical outcomes in many patients. Proper selection of patients at high risk for haematoma expansion seems crucial to improve outcomes. In this study, we aimed to prospectively validate the CT-angiography (CTA) spot sign for prediction of haematoma expansion.
Methods
PREDICT (predicting haematoma growth and outcome in intracerebral haemorrhage using contrast bolus CT) was a multicentre prospective observational cohort study. We recruited patients aged 18 years or older, with ICH smaller than 100 mL, and presenting at less than 6 h from symptom onset. Using two independent core laboratories, one neuroradiologist determined CTA spot-sign status, whereas another neurologist masked for clinical outcomes and …
Total citations
Scholar articles
AM Demchuk, D Dowlatshahi, D Rodriguez-Luna… - The Lancet Neurology, 2012