Authors
Webb Miller, Kate Rosenbloom, Ross C Hardison, Minmei Hou, James Taylor, Brian Raney, Richard Burhans, David C King, Robert Baertsch, Daniel Blankenberg, Sergei L Kosakovsky Pond, Anton Nekrutenko, Belinda Giardine, Robert S Harris, Svitlana Tyekucheva, Mark Diekhans, Thomas H Pringle, William J Murphy, Arthur Lesk, George M Weinstock, Kerstin Lindblad-Toh, Richard A Gibbs, Eric S Lander, Adam Siepel, David Haussler, W James Kent
Publication date
2007/12/1
Journal
Genome research
Volume
17
Issue
12
Pages
1797-1808
Publisher
Cold Spring Harbor Lab
Description
This article describes a set of alignments of 28 vertebrate genome sequences that is provided by the UCSC Genome Browser. The alignments can be viewed on the Human Genome Browser (March 2006 assembly) at http://genome.ucsc.edu, downloaded in bulk by anonymous FTP from http://hgdownload.cse.ucsc.edu/goldenPath/hg18/multiz28way, or analyzed with the Galaxy server at http://g2.bx.psu.edu. This article illustrates the power of this resource for exploring vertebrate and mammalian evolution, using three examples. First, we present several vignettes involving insertions and deletions within protein-coding regions, including a look at some human-specific indels. Then we study the extent to which start codons and stop codons in the human sequence are conserved in other species, showing that start codons are in general more poorly conserved than stop codons. Finally, an investigation of the …
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Scholar articles
W Miller, K Rosenbloom, RC Hardison, M Hou, J Taylor… - Genome research, 2007