Authors
Lucila Ohno-Machado, Zia Agha, Douglas S Bell, Lisa Dahm, Michele E Day, Jason N Doctor, Davera Gabriel, Maninder K Kahlon, Katherine K Kim, Michael Hogarth, Michael E Matheny, Daniella Meeker, Jonathan R Nebeker, pSCANNER team, Frederic Resnic, Dmitry Khodyakov, Lattice Armstead, Travis Nagler, Sam Morley, Nicholas Anderson, Dan Cooper, Dan Phillips, David Heber, Zhaoping Li, Michael K Ong, Ayan Patel, Marianne Zachariah, Jane C Burns, Lori B Daniels, Son Doan, Claudiu Farcas, Rita Germann-Kurtz, Xiaoqian Jiang, Hyeon-eui Kim, Paulina Paul, Howard Taras, Adriana Tremoulet, Shuang Wang, Wenhong Zhu, Douglas Berman, Angela Rizk-Jackson, Mike D’Arcy, Carl Kesselman, Tara Knight, Laura Pearlman, Paul Heidenreich, Dena Rifkin, Carl Stepnowsky, Tania Zamora, Scott L DuVall, Lewis J Frey, Jeffrey Scehnet, Brian C Sauer, Julio C Facelli, Ram K Gouripeddi, Jason Denton, Fern FitzHenry, James Fly, Vincent Messina, Freneka Minter, Lalit Nookala, Heidi Sullivan, Theodore Speroff, Dax Westerman
Publication date
2014/7/1
Journal
Journal of the American Medical Informatics Association
Volume
21
Issue
4
Pages
621-626
Publisher
BMJ Publishing Group
Description
Converging evidence from neuroimaging studies and computational modelling suggests an organization of language in a dual dorsal–ventral brain network: a dorsal stream connects temporoparietal with frontal premotor regions through the superior longitudinal and arcuate fasciculus and integrates sensorimotor processing, e.g. in repetition of speech. A ventral stream connects temporal and prefrontal regions via the extreme capsule and mediates meaning, e.g. in auditory comprehension. The aim of our study was to test, in a large sample of 100 aphasic stroke patients, how well acute impairments of repetition and comprehension correlate with lesions of either the dorsal or ventral stream. We combined voxelwise lesion-behaviour mapping with the dorsal and ventral white matter fibre tracts determined by probabilistic fibre tracking in our previous study in healthy subjects. We found that repetition impairments …
Scholar articles
L Ohno-Machado, Z Agha, DS Bell, L Dahm, ME Day… - Journal of the American Medical Informatics …, 2014