Authors
Stefan Klumpp, Melanie JI Muller, Reinhard Lipowsky
Publication date
2007/6/30
Journal
Traffic and Granular Flow'05
Pages
251
Publisher
Springer Verlag
Description
Molecular motors perform active movements along cytoskeletal filaments and drive the traffic of organelles and other cargo particles in cells. In contrast to the macroscopic traffic of cars, however, the traffic of molecular motors is characterized by a finite walking distance (or run length) after which a motor unbinds from the filament along which it moves. Unbound motors perform Brownian motion in the surrounding aqueous solution until they rebind to a filament. We use variants of driven lattice gas models to describe the interplay of their active movements, the unbound diffusion, and the binding/unbinding dynamics. If the motor concentration is large, motor-motor interactions become important and lead to a variety of cooperative traffic phenomena such as traffic jams on the filaments, boundary-induced phase transitions, and spontaneous symmetry breaking in systems with two species of motors. If the filament …
Total citations
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Scholar articles
S Klumpp, MJI Müller, R Lipowsky - Traffic and Granular Flow'05, 2007