Authors
Gosia Trynka, Alexandra Zhernakova, Jihane Romanos, Lude Franke, KA Hunt, Graham Turner, M Bruinenberg, GA Heap, M Platteel, AW Ryan, C De Kovel, GKT Holmes, PD Howdle, JRF Walters, DS Sanders, CJJ Mulder, ML Mearin, WHM Verbeek, V Trimble, FM Stevens, D Kelleher, D Barisani, MT Bardella, R McManus, DA Van Heel, C Wijmenga
Publication date
2009/8/1
Journal
Gut
Volume
58
Issue
8
Pages
1078-1083
Publisher
BMJ Publishing Group
Description
Objective
Our previous coeliac disease genome-wide association study (GWAS) implicated risk variants in the human leucocyte antigen (HLA) region and eight novel risk regions. To identify more coeliac disease loci, we selected 458 single nucleotide polymorphisms (SNPs) that showed more modest association in the GWAS for genotyping and analysis in four independent cohorts.
Design
458 SNPs were assayed in 1682 cases and 3258 controls from three populations (UK, Irish and Dutch). We combined the results with the original GWAS cohort (767 UK cases and 1422 controls); six SNPs showed association with p<1×10−04 and were then genotyped in an independent Italian coeliac cohort (538 cases and 593 controls).
Results
We identified two novel coeliac disease risk regions: 6q23.3 (OLIG3-TNFAIP3) and 2p16.1 (REL), both of which reached genome-wide significance in the combined analysis of all 2987 …
Total citations
Scholar articles
G Trynka, A Zhernakova, J Romanos, L Franke… - Gut, 2009