Authors
Peter J Snyder, Shalender Bhasin, Glenn R Cunningham, Alvin M Matsumoto, Alisa J Stephens-Shields, Jane A Cauley, Thomas M Gill, Elizabeth Barrett-Connor, Ronald S Swerdloff, Christina Wang, Kristine E Ensrud, Cora E Lewis, John T Farrar, David Cella, Raymond C Rosen, Marco Pahor, Jill P Crandall, Mark E Molitch, Denise Cifelli, Darlene Dougar, Laura Fluharty, Susan M Resnick, Thomas W Storer, Stephen Anton, Shehzad Basaria, Susan J Diem, Xiaoling Hou, Emile R Mohler III, J Kellogg Parsons, Nanette K Wenger, Bret Zeldow, J Richard Landis, Susan S Ellenberg
Publication date
2016/2/18
Journal
New England Journal of Medicine
Volume
374
Issue
7
Pages
611-624
Publisher
Massachusetts Medical Society
Description
Background
Serum testosterone concentrations decrease as men age, but benefits of raising testosterone levels in older men have not been established.
Methods
We assigned 790 men 65 years of age or older with a serum testosterone concentration of less than 275 ng per deciliter and symptoms suggesting hypoandrogenism to receive either testosterone gel or placebo gel for 1 year. Each man participated in one or more of three trials — the Sexual Function Trial, the Physical Function Trial, and the Vitality Trial. The primary outcome of each of the individual trials was also evaluated in all participants.
Results
Testosterone treatment increased serum testosterone levels to the mid-normal range for men 19 to 40 years of age. The increase in testosterone levels was associated with significantly increased sexual activity, as assessed by the Psychosexual Daily Questionnaire (P<0.001), as well as significantly …
Scholar articles
PJ Snyder, S Bhasin, GR Cunningham, AM Matsumoto… - New England Journal of Medicine, 2016