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Charge sharing between adjacent devices can lead to increased Single Event Upset (SEU) vulnerability. Key parameters affecting charge sharing are examined, and relative collected charge at the hit node and adjacent nodes are quantified. Results show that for a twin-well CMOS process, PMOS charge sharing can be effectively mitigated with the use of contacted guard-ring, whereas a combination of contacted guard-ring, nodal separation, and interdigitation is required to mitigate the NMOS charge sharing effect for the technology studied