Authors
Vijayagopal Gopalsamuthiram, Corshai Williams, Jeffrey Noble, Timothy F Jamison, B Frank Gupton, David R Snead
Publication date
2021/2
Journal
Synlett
Volume
32
Issue
03
Pages
326-328
Publisher
Georg Thieme Verlag KG
Description
A new route to MK-4482 was developed. The route replaces uridine with the more available and less expensive cytidine. Low-cost, simple reagents are used for the chemical transformations, and the yield is improved from 17% to 44%. A step is removed from the longest linear sequence, and these advancements are expected to expand access to MK-4482 should it become a viable drug substance.
Scholar articles
V Gopalsamuthiram, C Williams, J Noble, TF Jamison… - Synlett, 2021