Authors
Benjamin R Sabari, Alessandra Dall’Agnese, Ann Boija, Isaac A Klein, Eliot L Coffey, Krishna Shrinivas, Brian J Abraham, Nancy M Hannett, Alicia V Zamudio, John C Manteiga, Charles H Li, Yang E Guo, Daniel S Day, Jurian Schuijers, Eliza Vasile, Sohail Malik, Denes Hnisz, Tong Ihn Lee, Ibrahim I Cisse, Robert G Roeder, Phillip A Sharp, Arup K Chakraborty, Richard A Young
Publication date
2018/7/27
Journal
Science
Volume
361
Issue
6400
Pages
eaar3958
Publisher
American Association for the Advancement of Science
Description
INTRODUCTION
Mammalian genes that play prominent roles in healthy and diseased cellular states are often controlled by special DNA elements called super-enhancers (SEs). SEs are clusters of enhancers that are occupied by an unusually high density of interacting factors and drive higher levels of transcription than most typical enhancers. This high-density assembly at SEs has been shown to exhibit sharp transitions of formation and dissolution, forming in a single nucleation event and collapsing when chromatin factors or nucleation sites are deleted. These features led us to postulate that SEs are phase-separated multimolecular assemblies, also known as biomolecular condensates. Phase-separated condensates, such as the nucleolus and other membraneless cellular bodies, provide a means to compartmentalize and concentrate biochemical reactions within cells.
RATIONALE
SEs are formed by the …
Scholar articles
BR Sabari, A Dall'Agnese, A Boija, IA Klein, EL Coffey… - Science, 2018