Authors
Patrick R Harrington, Lisa Lindesmith, Boyd Yount, Christine L Moe, Ralph S Baric
Publication date
2002/12/1
Journal
Journal of virology
Volume
76
Issue
23
Pages
12335-12343
Publisher
American Society for Microbiology
Description
Attachment of Norwalk (NV), Snow Mountain (SMV), and Hawaii (HV) virus-like particles (VLPs) to specific ABH histo-blood group antigens was investigated by using human saliva and synthetic biotinylated carbohydrates. The three distinct Norwalk-like viruses (NLVs) have various capacities for binding ABH histo-blood group antigens, suggesting that different mechanisms for NLV attachment likely exist. Importantly, antisera from NV-infected human volunteers, as well as from mice inoculated with packaged Venezuelan equine encephalitis virus replicons expressing NV VLPs, blocked the ability of NV VLPs to bind synthetic H type 1, Leb, and H type 3, suggesting a potential mechanism for antibody-mediated neutralization of NV.
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PR Harrington, L Lindesmith, B Yount, CL Moe… - Journal of virology, 2002