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This chapter discusses some of the most pertinent of the interlinked questions with reference to information and communication technologies (ICT). The chapter starts with a brief discussion of concepts of responsibility and responsible innovation that allows the identification of important aspects that a responsible approach to ICT requires. It then builds a “Framework for Responsible Research and Innovation in Information and Communication technology” (FRRIICT) by discussing two different approaches to responsible (research and) innovation” (RRI), as represented by the two projects. This leads to a discussion of further research, as well as policy requirements that need to be addressed in order for research and development in ICT to live up to the expectations of responsibility.