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Membrane distillation (MD) is a non-isothermal separation process applied mainly in desalination for the treatment of saline aqueous solutions including brines for distilled water production by different technological configurations. Various experimental and theoretical investigations have been carried out in practically all related MD fields. However, no research study has been conducted yet evaluating the MD literature with data analysis, bibliometric methods, and machine learning approaches. This study includes an in-depth review of MD published papers in refereed international journals. Interesting statistical and graphical information on MD is presented. By using different indexes of bibliometric analysis, significant papers, authors more active in MD research, and the corresponding institutions and countries that have contributed most to the progress of MD technology are presented together with the …