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Soil heavy metal contamination is a widespread phenomenon that occurs naturally or as a result of anthropogenic activities such as mining, smelting, fossil fuel combustion and agriculture. Heavy metal accumulation in agricultural soils is a major environmental constraint leading to lower crop productivity, and reduced food/feed safety. Among the non-food crops, medicinal and aromatics plants have been proposed as alternative crops in heavy metal contaminated soils, where an environmental obstacle such as heavy metal can be exploited to elicit the biosynthesis of invaluable secondary metabolites. Plants use different strategies to cope with the heavy metals entered their cells. Tolerance to a specific heavy metal is controlled by a complex inter-related cascade of morphological, physiological, biochemical, and genetic mechanisms. Heavy metal ions bind to the protein groups and are able to replace specific …