Authors
Pasan Fernando, Lynn A Megeney
Publication date
2007/1
Journal
The FASEB Journal
Volume
21
Issue
1
Pages
8-17
Publisher
Federation of American Societies for Experimental Biology
Description
The benefits of apoptosis for a multicellular organism are obvious and fit the current dogma that the maintenance and viability of such organisms are dependent on the selective elimination of unneeded or deleterious cell types. However, self destruction at the level of the individual cell defies the most basic precepts of biology (sustaining life). If apoptosis is viewed through this construct then one question becomes paramount, i.e., why would an individual cell and its progeny develop, retain, or evolve a mechanism the sole purpose of which is to eliminate itself? In consideration of such a paradox, it is reasonable to postulate that prospective apoptotic pathways co‐evolved with and or were co‐opted from another basic cell function(s) that did not involve the death of the cell per se. In the following article, we present the hypothesis that the conserved biochemical pathways of apoptosis are integral components of …
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