Authors
Cristiana Bianco, Oveis Jamialahmadi, Serena Pelusi, Guido Baselli, Paola Dongiovanni, Irene Zanoni, Luigi Santoro, Silvia Maier, Antonio Liguori, Marica Meroni, Vittorio Borroni, Roberta D’Ambrosio, Rocco Spagnuolo, Anna Alisi, Alessandro Federico, Elisabetta Bugianesi, Salvatore Petta, Luca Miele, Umberto Vespasiani-Gentilucci, Quentin M Anstee, Felix Stickel, Jochen Hampe, Janett Fischer, Thomas Berg, Anna Ludovica Fracanzani, Giorgio Soardo, Helen Reeves, Daniele Prati, Stefano Romeo, Luca Valenti
Publication date
2021/4/1
Journal
Journal of hepatology
Volume
74
Issue
4
Pages
775-782
Publisher
Elsevier
Description
Background & Aims
Hepatocellular carcinoma (HCC) risk stratification in individuals with dysmetabolism is a major unmet need. Genetic predisposition contributes to non-alcoholic fatty liver disease (NAFLD). We aimed to exploit robust polygenic risk scores (PRS) that can be evaluated in the clinic to gain insight into the causal relationship between NAFLD and HCC, and to improve HCC risk stratification.
Methods
We examined at-risk individuals (NAFLD cohort, n = 2,566; 226 with HCC; and a replication cohort of 427 German patients with NAFLD) and the general population (UK Biobank [UKBB] cohort, n = 364,048; 202 with HCC). Variants in PNPLA3-TM6SF2-GCKR-MBOAT7 were combined in a hepatic fat PRS (PRS-HFC), and then adjusted for HSD17B13 (PRS-5).
Results
In the NAFLD cohort, the adjusted impact of genetic risk variants on HCC was proportional to the predisposition to fatty liver (p = 0.002) with …
Scholar articles
C Bianco, O Jamialahmadi, S Pelusi, G Baselli… - Journal of hepatology, 2021