Authors
Goutham Narla, Karen E Heath, Helen L Reeves, Dan Li, Luciana E Giono, Alec C Kimmelman, Marc J Glucksman, Jyothsna Narla, Francis J Eng, Andrew M Chan, Anna C Ferrari, John A Martignetti, Scott L Friedman
Publication date
2001/12/21
Journal
Science
Volume
294
Issue
5551
Pages
2563-2566
Publisher
American Association for the Advancement of Science
Description
Kruppel-like factor 6 (KLF6) is a zinc finger transcription factor of unknown function. Here, we show that theKLF6 gene is mutated in a subset of human prostate cancer. Loss-of-heterozygosity analysis revealed that one KLF6allele is deleted in 77% (17 of 22) of primary prostate tumors. Sequence analysis of the retained KLF6 allele revealed mutations in 71% of these tumors. Functional studies confirm that whereas wild-type KLF6 up-regulates p21 (WAF1/CIP1) in a p53-independent manner and significantly reduces cell proliferation, tumor-derived KLF6 mutants do not. Our data suggest thatKLF6 is a tumor suppressor gene involved in human prostate cancer.
Total citations
Scholar articles
G Narla, KE Heath, HL Reeves, D Li, LE Giono… - Science, 2001