Authors
Philip J Johnson, Sarah Berhane, Chiaki Kagebayashi, Shinji Satomura, Mabel Teng, Helen L Reeves, James O'Beirne, Richard Fox, Anna Skowronska, Daniel Palmer, Winnie Yeo, Frankie Mo, Paul Lai, Mercedes Iñarrairaegui, Stephen L Chan, Bruno Sangro, Rebecca Miksad, Toshifumi Tada, Takashi Kumada, Hidenori Toyoda
Publication date
2015/2/20
Journal
Journal of Clinical Oncology
Volume
33
Issue
6
Pages
550-558
Publisher
American Society of Clinical Oncology
Description
Purpose
Most patients with hepatocellular carcinoma (HCC) have associated chronic liver disease, the severity of which is currently assessed by the Child-Pugh (C-P) grade. In this international collaboration, we identify objective measures of liver function/dysfunction that independently influence survival in patients with HCC and then combine these into a model that could be compared with the conventional C-P grade.
Patients and Methods
We developed a simple model to assess liver function, based on 1,313 patients with HCC of all stages from Japan, that involved only serum bilirubin and albumin levels. We then tested the model using similar cohorts from other geographical regions (n = 5,097) and other clinical situations (patients undergoing resection [n = 525] or sorafenib treatment for advanced HCC [n = 1,132]). The specificity of the model for liver (dys)function was tested in patients with chronic liver …
Scholar articles
PJ Johnson, S Berhane, C Kagebayashi, S Satomura… - Journal of Clinical Oncology, 2015