Authors
I Gabilondo, A Saiz, L Galán, V González, R Jadraque, L Sabater, A Sans, A Sempere, A Vela, F Villalobos, M Viñals, P Villoslada, F Graus
Publication date
2011/9/6
Journal
Neurology
Volume
77
Issue
10
Pages
996-999
Publisher
Lippincott Williams & Wilkins
Description
Objective
The clinical characteristics of patients with relapsing anti–NMDA receptor (NMDAR) encephalitis are not well-defined. In this study, we report the clinical profile and outcome of relapses in a series of anti-NMDAR encephalitis.
Methods
We did a retrospective review of relapses that occurred in 25 patients with anti-NMDAR encephalitis. Relapses were defined as any new psychiatric or neurologic syndrome, not explained by other causes, which improved after immunotherapy or, less frequently, spontaneously.
Results
A total of 13 relapses were identified in 6 patients. Four of them had several, 2 to 4, relapses. There was a median delay of 2 years (range 0.5 to 13 years) for the first relapse. Median relapse rate was 0.52 relapses/patient-year. Relapse risk was higher in patients who did not receive immunotherapy in the first episode (p = 0.009). Most cases (53%) presented partial syndromes of the typical anti …
Total citations
Scholar articles
I Gabilondo, A Saiz, L Galán, V González, R Jadraque… - Neurology, 2011