Authors
Ho Jin Kim, Friedemann Paul, Marco A Lana-Peixoto, Silvia Tenembaum, Nasrin Asgari, Jacqueline Palace, Eric C Klawiter, Douglas K Sato, Jerome de Seze, Jens Wuerfel, Brenda L Banwell, Pablo Villoslada, Albert Saiz, Kazuo Fujihara, Su-Hyun Kim, With The Guthy-Jackson Charitable Foundation NMO International Clinical Consortium & Biorepository, Friedemann Paul, Jens Wuerfel, Philippe Cabre, Romain Marignier, Jérôme de Seze, Thomas Tedder, Juan P Garrahan, Silvia Tenembaum, Danielle van Pelt, Simon Broadley, Albert Saiz, Pablo Villoslada, Michael Levy, Tanuja Chitnis, Eric C Klawiter, Dean Wingerchuk, Ho Jin Kim, Lekha Pandit, Ilya Kister, Maria Isabel Leite, Jacqueline Palace, Metha Apiwattanakul, Ingo Kleiter, Naraporn Prayoonwiwat, May Han, Kerstin Hellwig, Brenda Banwell, Katja van Herle, Jacinta Behne, Gareth John, D Craig Hooper, Kazuo Fujihara, Ichiro Nakashima, Douglas Sato, Anthony Traboulsee, Michael R Yeaman, Emmanuelle Waubant, Scott Zamvil, Jeffrey Bennett, Marco Lana-Peixoto, Benjamin Greenberg, Olaf Stuve, Orhan Aktas, Jens Wuerfel, Terry J Smith, Nasrin Asgari, Anu Jacob, Kevin O'Connor
Publication date
2015/3/17
Source
Neurology
Volume
84
Issue
11
Pages
1165-1173
Publisher
Lippincott Williams & Wilkins
Description
Since its initial reports in the 19th century, neuromyelitis optica (NMO) had been thought to involve only the optic nerves and spinal cord. However, the discovery of highly specific anti–aquaporin-4 antibody diagnostic biomarker for NMO enabled recognition of more diverse clinical spectrum of manifestations. Brain MRI abnormalities in patients seropositive for anti–aquaporin-4 antibody are common and some may be relatively unique by virtue of localization and configuration. Some seropositive patients present with brain involvement during their first attack and/or continue to relapse in the same location without optic nerve and spinal cord involvement. Thus, characteristics of brain abnormalities in such patients have become of increased interest. In this regard, MRI has an increasingly important role in the differential diagnosis of NMO and its spectrum disorder (NMOSD), particularly from multiple sclerosis …
Scholar articles
HJ Kim, F Paul, MA Lana-Peixoto, S Tenembaum… - Neurology, 2015