Authors
Matthias G Pauthner, Joseph P Nkolola, Colin Havenar-Daughton, Ben Murrell, Samantha M Reiss, Raiza Bastidas, Jérémie Prévost, Rebecca Nedellec, Benjamin von Bredow, Peter Abbink, Christopher A Cottrell, Daniel W Kulp, Talar Tokatlian, Bartek Nogal, Matteo Bianchi, Hui Li, Jeong Hyun Lee, Salvatore T Butera, David T Evans, Lars Hangartner, Andrés Finzi, Ian A Wilson, Richard T Wyatt, Darrell J Irvine, William R Schief, Andrew B Ward, Rogier W Sanders, Shane Crotty, George M Shaw, Dan H Barouch, Dennis R Burton
Publication date
2019/1/15
Journal
Immunity
Volume
50
Issue
1
Pages
241-252. e6
Publisher
Elsevier
Description
Passive administration of HIV neutralizing antibodies (nAbs) can protect macaques from hard-to-neutralize (tier 2) chimeric simian-human immunodeficiency virus (SHIV) challenge. However, conditions for nAb-mediated protection after vaccination have not been established. Here, we selected groups of 6 rhesus macaques with either high or low serum nAb titers from a total of 78 animals immunized with recombinant native-like (SOSIP) Env trimers. Repeat intrarectal challenge with homologous tier 2 SHIVBG505 led to rapid infection in unimmunized and low-titer animals. High-titer animals, however, demonstrated protection that was gradually lost as nAb titers waned over time. An autologous serum ID50 nAb titer of ∼1:500 afforded more than 90% protection from medium-dose SHIV infection. In contrast, antibody-dependent cellular cytotoxicity and T cell activity did not correlate with protection. Therefore, Env …
Scholar articles
MG Pauthner, JP Nkolola, C Havenar-Daughton… - Immunity, 2019