Authors
Paul L Chesis, David E Levin, Martyn T Smith, Lars Ernster, Bruce N Ames
Publication date
1984/3
Journal
Proceedings of the National Academy of Sciences
Volume
81
Issue
6
Pages
1696-1700
Description
The mutagenicity of various quinones, a class of compounds widely distributed in nature, is demonstrated in the Salmonella TA104 tester strain. The metabolic pathways by which four quinones, menadione, benzo[a]pyrene 3,6-quinone, 9,10-phenanthrenequinone, and danthron, caused mutagenicity in this test system were investigated in detail as were the detoxification pathways. The two-electron reduction of these quinones by NAD(P)H-quinone oxidoreductase (DT-diaphorase) was not mutagenic, whereas the one-electron reduction, catalyzed by NADPH-cytochrome P-450 reductase, was mutagenic, except for danthron, which was only slightly mutagenic. The mutagenicity of the quinones via this pathway was found to be attributable to the generation of oxygen radicals. The cytochrome P-450 monooxygenase also played a significant role in the detoxification and bioactivation of these quinones. For example …
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Scholar articles
PL Chesis, DE Levin, MT Smith, L Ernster, BN Ames - Proceedings of the National Academy of Sciences, 1984