Authors
Jonathan R Terman, Anna Kashina
Publication date
2013/2/1
Source
Current opinion in cell biology
Volume
25
Issue
1
Pages
30-38
Publisher
Elsevier Current Trends
Description
Many of the best-studied actin regulatory proteins use non-covalent means to modulate the properties of actin. Yet, actin is also susceptible to covalent modifications of its amino acids. Recent work is increasingly revealing that actin processing and its covalent modifications regulate important cellular events. In addition, numerous pathogens express enzymes that specifically use actin as a substrate to regulate their hosts’ cells. Actin post-translational alterations have been linked to different normal and disease processes and the effects associated with metabolic and environmental stressors. Herein, we highlight specific co-translational and post-translational modifications of actin and discuss the current understanding of the role that these modifications play in regulating actin.
Scholar articles
JR Terman, A Kashina - Current opinion in cell biology, 2013