Authors
Marina Karakozova, Marina Kozak, Catherine CL Wong, Aaron O Bailey, John R Yates III, Alexander Mogilner, Henry Zebroski, Anna Kashina
Publication date
2006/7/14
Journal
Science
Volume
313
Issue
5784
Pages
192-196
Publisher
American Association for the Advancement of Science
Description
Posttranslational arginylation is critical for mouse embryogenesis, cardiovascular development, and angiogenesis, but its molecular effects and the identity of proteins arginylated in vivo are unknown. We found that β-actin was arginylated in vivo to regulate actin filament properties, β-actin localization, and lamella formation in motile cells. Arginylation of β-actin apparently represents a critical step in the actin N-terminal processing needed for actin functioning in vivo. Thus, posttranslational arginylation of a single protein target can regulate its intracellular function, inducing global changes on the cellular level, and may contribute to cardiovascular development and angiogenesis.
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Scholar articles
M Karakozova, M Kozak, CCL Wong, AO Bailey… - Science, 2006