Authors
Giuseppe Di Pede, Pedro Mena, Letizia Bresciani, Mariem Achour, Rosa M Lamuela-Raventós, Ramon Estruch, Rikard Landberg, Sabine E Kulling, David Wishart, Ana Rodriguez-Mateos, Michael N Clifford, Alan Crozier, Claudine Manach, Daniele Del Rio
Publication date
2024/3/1
Source
Antioxidants & redox signaling
Volume
40
Issue
7-9
Pages
510-541
Publisher
Mary Ann Liebert, Inc., publishers
Description
Significance: Hydroxycinnamic acids (HCAs) are the main phenolic acids in the western diet. Harmonizing the available information on the absorption, distribution, metabolism, and excretion (ADME) of HCAs is fundamental to unraveling the compounds responsible for their health effects. This work systematically assessed pharmacokinetics, including urinary recovery, and bioavailability of HCAs and their metabolites, based on literature reports.
Recent Advances: Forty-seven intervention studies with coffee, berries, herbs, cereals, tomato, orange, grape products, and pure compounds, as well as other sources yielding HCA metabolites, were included. Up to 105 HCA metabolites were collected, mainly acyl-quinic and C6-C3 cinnamic acids. C6-C3 cinnamic acids, such as caffeic and ferulic acid, reached the highest blood concentrations (maximum plasma concentration [Cmax] = 423 nM), with time to reach Cmax …
Scholar articles
G Di Pede, P Mena, L Bresciani, M Achour… - Antioxidants & redox signaling, 2024