Authors
Stina Lindmark, Lars Lönn, Urban Wiklund, Magnus Tufvesson, Tommy Olsson, Jan W Eriksson
Publication date
2005/4
Journal
Obesity Research
Volume
13
Issue
4
Pages
717-728
Publisher
Blackwell Publishing Ltd
Description
Objective: To evaluate the interplay among abdominal adipose tissue distribution, the cortisol axis, the autonomic nervous system, and insulin resistance.
Research Methods and Procedures: Two age‐, sex‐, and BMI‐matched groups were studied. Fifteen subjects were first‐degree relatives of patients with type 2 diabetes (R), and 15 had no family history of diabetes (controls, C). A hyperinsulinemic euglycemic clamp, cortisol measurements, and analysis of heart rate variability (HRV) were performed. Computed tomography was performed in a subgroup (n = 9 + 9) to determine abdominal adipose tissue distribution.
Results: R tended to be less insulin‐sensitive than C (M value 9.2 ± 1.0 vs 10.3 ± 0.7 mg/kg per minute, not significant). Stimulation with tetracosactin or corticotropin releasing hormone yielded lower peak serum cortisol levels in R (p = 0.03 and p = 0.06, respectively). The amount of visceral abdominal …
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S Lindmark, L Lönn, U Wiklund, M Tufvesson, T Olsson… - Obesity Research, 2005