Authors
Lucio Giordano, Aglaia Vignoli, Patrizia Accorsi, Jessica Galli, Marianna Pezzella, Monica Traverso, Silvia Battaglia, Maria Giuseppina Baglietto, Francesca Beccaria, Caterina Cerminara, Silvia Gambara, Ennio Del Giudice, Giovanni Crichiutti, Francesca Bisulli, Mariangela Pinci, Paolo Tinuper, Eleonora Briatore, Stefano Calzolari, Antonietta Coppola, Maria Paola Canevini, Giuseppe Capovilla, Salvatore Striano, Federico Zara, Carlo Minetti, Pasquale Striano
Publication date
2011/8/1
Journal
Epilepsy research
Volume
95
Issue
3
Pages
221-226
Publisher
Elsevier
Description
PURPOSE
To investigate the electroclinical features and the outcome of patients with typical absences starting before the 3 years of life.
METHODS
We reviewed the clinical data of patients with absences started before 3 years observed over a 15-year period. Mutation analysis of SLC2A1 (GLUT-1) gene was performed when possible. Their clinical features were compared with those of subjects with a diagnosis of childhood absence epilepsy (CAE).
RESULTS
Among 33 children with absence epilepsy starting before 3 years of life, there were 20 boys and 13 girls. Mean seizure onset was at 28.0±8.3 (range: 8–36) months of life. Two children displayed borderline intellectual functioning at long-term follow-up. Twenty-eight (85%) patients showed excellent response to therapy. Three subjects evolved into a different form of idiopathic generalized epilepsy (IGE). No SLC2A1 mutation was identified in 20 (60.6 …
Scholar articles
L Giordano, A Vignoli, P Accorsi, J Galli, M Pezzella… - Epilepsy research, 2011