Authors
Beben Benyamin, BSt Pourcain, Oliver S Davis, Gail Davies, Narelle K Hansell, M-JA Brion, RM Kirkpatrick, Rolieke AM Cents, Sanja Franić, MB Miller, CMA Haworth, Emma Meaburn, Tom S Price, David M Evans, Nicholas Timpson, John Kemp, Susan Ring, Wendy McArdle, Sarah E Medland, Jian Yang, SE Harris, David C Liewald, Paul Scheet, Xiangjun Xiao, JJ Hudziak, Eco JC de Geus, VWV Jaddoe, John M Starr, FC Verhulst, Craig Pennell, Henning Tiemeier, William G Iacono, Lyle J Palmer, Grant W Montgomery, Nicholas G Martin, Dorret I Boomsma, Danielle Posthuma, Matt McGue, Margaret J Wright, George Davey Smith, Ian J Deary, Robert Plomin, Peter M Visscher
Publication date
2014/2
Journal
Molecular psychiatry
Volume
19
Issue
2
Pages
253-258
Publisher
Nature Publishing Group
Description
Intelligence in childhood, as measured by psychometric cognitive tests, is a strong predictor of many important life outcomes, including educational attainment, income, health and lifespan. Results from twin, family and adoption studies are consistent with general intelligence being highly heritable and genetically stable throughout the life course. No robustly associated genetic loci or variants for childhood intelligence have been reported. Here, we report the first genome-wide association study (GWAS) on childhood intelligence (age range 6–18 years) from 17 989 individuals in six discovery and three replication samples. Although no individual single-nucleotide polymorphisms (SNPs) were detected with genome-wide significance, we show that the aggregate effects of common SNPs explain 22–46% of phenotypic variation in childhood intelligence in the three largest cohorts (P= 3.9× 10− 15, 0.014 and 0.028 …
Scholar articles
B Benyamin, BS Pourcain, OS Davis, G Davies… - Molecular psychiatry, 2014