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To evaluate the possibility that fibrinogen represents a cardiovascular risk factor.

A computerized literature search (1980 to 1992) identified all published epidemiologic studies on fibrinogen and cardiovascular disease. Clinical and basic research data were found by separate searches. References of all papers thus obtained were studied and relevant papers included.

Six prospective epidemiologic studies were included in a meta-analysis (one study was excluded because the study population was nonrepresentative). Clinical papers were reviewed separately for other evidence of causation.

The correlation of fibrinogen levels on the subsequent incidence of myocardial infarction, stroke, and peripheral arterial occlusive disease was assessed …