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▪ Objectives: To determine the prevalence of antibodies to hepatitis C virus (HCV) in female sexual partners of multitransfused men with hemophilia and to compare the frequency of transmission of HCV and human immunodeficiency virus (HIV).

▪ Study Design: Cross-sectional measurement of HCV and HIV antibodies.

▪ Setting: Ten hemophilia treatment centers.

▪ Patients: A total of 234 female sexual partners of 231 multitransfused men with hemophilia.

▪ Measurements and Main Results: The prevalence of antibodies to HCV (anti-HCV) among female sexual partners of HCV-positive men was 5 of 194 (2.6%). Anti-HIV prevalence among female sexual partners of HIV-positive men was 25 of 196 (12.8%). Five (3%) of the 164 female sexual partners of HIV-positive/HCV-positive men were infected with HCV compared with none of the 30 female sexual partners of HIV-negative/HCV-positive …