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Chronic hepatitis C (HCV) infection is currently one of the most clinically relevant comorbidities in the HIV population; overall, it affects one third of HIV-positive individuals [1]. Progression to end-stage liver disease occurs faster in coinfected patients [2–4] and decompensated cirrhosis is one of the main causes of hospitalization and death in this population [5–8]. However, the risk of hepatotoxicity using antiretroviral drugs is increased in subjects with underlying HCV infection [9, 10]. Therefore, the optimal management of chronic HCV in HIV-positive patients is currently a priority.

Several guidelines for caring for HCV infection in HIV-positive individuals have been released [11–15]. Because new and relevant information has recently appeared, it is convenient to update them. Eleven areas have been identified in which new recommendations are particularly needed: