Authors
Thomas R O'Brien, William A Blattner, David Waters, M Elaine Eyster, Margaret W Hilgartner, Alan R Cohen, Naomi Luban, Angelos Hatzakis, Louis M Aledort, Philip S Rosenberg, Wendell J Miley, Barbara L Kroner, James J Goedert
Publication date
1996/7/10
Journal
Jama
Volume
276
Issue
2
Pages
105-110
Publisher
American Medical Association
Description
Objective
—To determine if the long-term incidence of the acquired immunodeficiency syndrome (AIDS) is related to human immunodeficiency virus type 1 (HIV-1) RNA levels measured early in HIV-1 infection.
Design
—Epidemiologic cohort study.
Setting
—Five hemophilia treatment centers in the United States.
Subjects
—A total of 165 subjects with hemophilia and HIV-1 infection (age at HIV-1 seroconversion, 1-66 years) followed from 1979 to 1995.
Methods
—The HIV-1 RNA level was measured by polymerase chain reaction over a range of 200 to 1 million or more HIV-1 RNA copies/mL in archived serum specimens collected 12 to 36 months (median, 27 months) after the estimated date of HIV-1 seroconversion. Kaplan-Meier methods were used to examine the risk of AIDS and proportional hazards models were used to estimate relative hazards.
Results
—The HIV-1 RNA values were similar in subjects younger …
Total citations
Scholar articles
TR O'Brien, WA Blattner, D Waters, ME Eyster… - Jama, 1996