Authors
Francesca Nicosia, Antonella Alberici, Luisa Benussi, Laura Gasparini, Roberta Ghidoni, Federica Mazzoli, Orazio Zanetti, Giovanni Battista Frisoni, Cristina Geroldi, Giuliano Binetti
Publication date
2001
Journal
Dementia and geriatric cognitive disorders
Volume
12
Issue
5
Pages
305-308
Publisher
Karger Publishers
Description
A correlation between a 5-nucleotide deletion polymorphism in the A2M gene and an enhanced risk of developing Alzheimer’s disease (AD) was reported. We studied this polymorphism in sporadic AD patients and patients with frontotemporal dementia (FTD) by using an electrophoretical separation of PCR products on a Metaphor gel. Our results did not show any significant difference between A2M-2 allelic frequency (p = 0.89) or genotype frequency (p = 0.97) in the two different clinical series and in control subjects. The frequencies were not significantly different after stratification by APOE Ε4 status.
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Scholar articles
F Nicosia, A Alberici, L Benussi, L Gasparini, R Ghidoni… - Dementia and geriatric cognitive disorders, 2001