Authors
Matthew T James, William A Ghali, Merril L Knudtson, Pietro Ravani, Marcello Tonelli, Peter Faris, Neesh Pannu, Braden J Manns, Scott W Klarenbach, Brenda R Hemmelgarn
Publication date
2011/2/1
Journal
Circulation
Volume
123
Issue
4
Pages
409-416
Publisher
Lippincott Williams & Wilkins
Description
Background
Acute kidney injury (AKI) is associated with early mortality after percutaneous coronary revascularization procedures, but its prognostic relevance to long-term clinical outcomes remains controversial.
Methods and Results
We conducted a retrospective study of 14 782 adults who received coronary angiography in the province of Alberta, Canada, between 2004 and 2006. AKI was identified on the basis of changes in serum creatinine concentration within 7 days of the procedure according to AKI Network criteria. The associations between AKI and long-term outcomes, including mortality, end-stage renal disease, and cardiovascular and renal hospitalizations, were studied with the use of Cox regression of multiple failure times. The adjusted risk of death increased with increasing severity of AKI; compared with no AKI, the adjusted hazard ratio for death was 2.00 (95% confidence interval, 1.69 to 2.36) with …
Total citations
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