Authors
Kristian B Filion, Dan Chateau, Laura E Targownik, Andrea Gershon, Madeleine Durand, Hala Tamim, Gary F Teare, Pietro Ravani, Pierre Ernst, Colin R Dormuth, CNODES Investigators
Publication date
2014/4/1
Journal
Gut
Volume
63
Issue
4
Pages
552-558
Publisher
BMJ Publishing Group
Description
Objective
Previous observational studies suggest that the use of proton pump inhibitors (PPIs) may increase the risk of hospitalisation for community-acquired pneumonia (HCAP). However, the potential presence of confounding and protopathic biases limits the conclusions that can be drawn from these studies. Our objective was, therefore, to examine the risk of HCAP with PPIs prescribed prophylactically in new users of non-steroidal anti-inflammatory drugs (NSAIDs).
Design
We formed eight restricted cohorts of new users of NSAIDs, aged ≥40 years, using a common protocol in eight databases (Alberta, Saskatchewan, Manitoba, Ontario, Quebec, Nova Scotia, US MarketScan and the UK's General Practice Research Database (GPRD)). This specific patient population was studied to minimise bias due to unmeasured confounders. High-dimensional propensity scores were used to estimate site-specific adjusted …
Scholar articles
KB Filion, D Chateau, LE Targownik, A Gershon… - Gut, 2014