Authors
Enrico Imbasciati, Gina Gregorini, Gianfranca Cabiddu, Linda Gammaro, Giancarlo Ambroso, Antonio Del Giudice, Pietro Ravani, Collaborative Group, Rene e Gravidanza
Publication date
2007/6/1
Journal
American journal of kidney diseases
Volume
49
Issue
6
Pages
753-762
Publisher
WB Saunders
Description
BACKGROUND
Prognostic criteria to inform women with moderate to severe renal insufficiency who wish to bear children are not well established.
STUDY DESIGN
Longitudinal multicenter cohort study.
SETTINGS & PARTICIPANTS
Nondiabetic white women with pregnancies proceeded beyond the 20th week and estimated glomerular filtration rate (GFR) less than 60 mL/min/1.73 m2 (<1 mL/s/1.73 m2) before conception.
PREDICTORS
Baseline GFR and proteinuria (exposure); other clinical characteristics at conception (covariates).
OUTCOMES & MEASUREMENTS
Difference in GFR decreases before conception versus after delivery (mixed linear models); low birth weight (<2,500 g), and maternal renal survival (logistic and Cox regressions).
RESULTS
49 women were studied. Mean serum creatinine and GFR at conception were 2.1 ± 1 (SD) mg/dL (186 ± 88 μmol/L) and 35 ± 12 mL/min/1.73 m2 (0.58 ± 0.2 mL …
Total citations
Scholar articles
E Imbasciati, G Gregorini, G Cabiddu, L Gammaro… - American journal of kidney diseases, 2007