Authors
Matteo Lambertini, Halle CF Moore, Robert CF Leonard, Sibylle Loibl, Pamela Munster, Marco Bruzzone, Luca Boni, Joseph M Unger, Richard A Anderson, Keyur Mehta, Susan Minton, Francesca Poggio, Kathy S Albain, Douglas JA Adamson, Bernd Gerber, Amy Cripps, Gianfilippo Bertelli, Sabine Seiler, Marcello Ceppi, Ann H Partridge, Lucia Del Mastro
Publication date
2018/7/1
Source
Journal of clinical oncology
Volume
36
Issue
19
Pages
1981-1990
Publisher
American Society of Clinical Oncology
Description
Purpose
The role of temporary ovarian suppression with gonadotropin-releasing hormone agonists (GnRHa) during chemotherapy as a strategy to preserve ovarian function and fertility in premenopausal women remains controversial. This systematic review and meta-analysis using individual patient–level data was conducted to better assess the efficacy and safety of this strategy in patients with early breast cancer.
Methods
The trials in which premenopausal women with early breast cancer were randomly assigned to receive (neo)adjuvant chemotherapy alone or with concurrent GnRHa were eligible for inclusion. Primary end points were premature ovarian insufficiency (POI) rate and post-treatment pregnancy rate. Disease-free survival and overall survival were secondary end points. Because each study represents a cluster, statistical analyses were performed using a random effects model.
Results
A total of 873 …
Scholar articles
M Lambertini, HCF Moore, RCF Leonard, S Loibl… - Journal of clinical oncology, 2018
M Lambertini, HCF Moore, RCF Leonard, S Loibl… - Cancer Research, 2018