Authors
David A Giljohann, Dwight S Seferos, Pinal C Patel, Jill E Millstone, Nathaniel L Rosi, Chad A Mirkin
Publication date
2020/8/31
Book
Spherical Nucleic Acids
Pages
413-423
Publisher
Jenny Stanford Publishing
Description
Spherical Nucleic Acids Page 1 Chapter 15 Oligonucleotide Loading Determines Cellular
Uptake of DNA-Modified Gold Nanoparticles* David A. Giljohann, Dwight S. Seferos, Pinal C.
Patel, Jill E. Millstone, Nathaniel L. Rosi, and Chad A. Mirkin Department of Chemistry,
Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA International Institute
for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
[email protected] The nanoparticles is cellular in int vestig ernalization ated.
Uptake of is dependent oligonucleotide-modified of the oligonucleotide loading on the surface
of the particles, on the density higher densities lead to gr er uptake. Densel w e nanoparticles
adsorb a large number of eat proteins on the nanoparticle y functionalized her *R JE, R uptak
(2007) American Chemical Society eprinted with permission DN . L. and Mir from Giljohann, DA…
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DA Giljohann, DS Seferos, PC Patel, JE Millstone… - Spherical Nucleic Acids, 2020