Authors
1958 Birth Cohort Controls: Jones Richard W 18 McArdle Wendy L 18 Ring Susan M 18 Strachan David P 19 Pembrey Marcus 18 20, Bipolar Disorder (Aberdeen): Breen Gerome 21 Clair David St 21, (Birmingham): Caesar Sian 22 Gordon-Smith Katharine 22 23 Jones Lisa 22, (Cardiff): Fraser Christine 23 Green Elaine K 23 Grozeva Detelina 23 Hamshere Marian L 23 Holmans Peter A 23 Jones Ian R 23 Kirov George 23 Moskivina Valentina 23 Nikolov Ivan 23 O'Donovan Michael C 23 Owen Michael J 23 Craddock Nick 23, (London): Collier David A 24 Elkin Amanda 24 Farmer Anne 24 Williamson Richard 24 McGuffin Peter 24, (Newcastle): Young Allan H 25 Ferrier I Nicol 25, Coronary Artery Disease (Leeds): Ball Stephen G 26 Balmforth Anthony J 26 Barrett Jennifer H 26 Bishop Timothy D 26 Iles Mark M 26 Maqbool Azhar 26 Yuldasheva Nadira 26 Hall Alistair S 26, (Leicester): Braund Peter S 10 Burton Paul R 1 Dixon Richard J 10 Mangino Massimo 10 Stevens Suzanne 10 Tobin Martin D 1 Thompson John R 1 Samani Nilesh J 10, Crohn's Disease (Cambridge): Bredin Francesca 27 Tremelling Mark 27 Parkes Miles 27, (Edinburgh): Drummond Hazel 28 Lees Charles W 28 Nimmo Elaine R 28 Satsangi Jack 28, (London): Fisher Sheila A 29 Forbes Alastair 30 Lewis Cathryn M 29 Onnie Clive M 29 Prescott Natalie J 29 Sanderson Jeremy 31 Matthew Christopher G 29, (Newcastle): Barbour Jamie 32 Mohiuddin M Khalid 32 Todhunter Catherine E 32 Mansfield John C 32, (Oxford): Ahmad Tariq 33 Cummings Fraser R 33 Jewell Derek P 33, Hypertension (Aberdeen): Webster John 34, (Cambridge): Brown Morris J 35 Clayton David G 2, (Evry, France): Lathrop Mark G 36, (Glasgow): Connell John 37 Dominiczak Anna 37, (Leicester): Samani Nilesh J 10, (London): Marcano Carolina A Braga 38 Burke Beverley 38 Dobson Richard 38 Gungadoo Johannie 38 Lee Kate L 38 Munroe Patricia B 38 Newhouse Stephen J 38 Onipinla Abiodun 38 Wallace Chris 38 Xue Mingzhan 38 Caulfield Mark 38, (Oxford): Farrall Martin 39, Rheumatoid Arthritis: Barton Anne 40, Type 1 Diabetes: Clayton David G 2 Dunger David B 2 41 Nutland Sarah 2 Stevens Helen E 2 Walker Neil M 2 Widmer Barry 2 41 Todd John A 2, Type 2 Diabetes (Exeter): Frayling Timothy M 42 43 Freathy Rachel M 42 43 Lango Hana 42 43 Perry John RB 42 43 Shields Beverley M 43 Weedon Michael N 42 43 Hattersley Andrew T 42 43, (London): Hitman Graham A 44, (Newcastle): Walker Mark 45, (Oxford): Elliott Kate S 3 7 Groves Christopher J 7 Lindgren Cecilia M 3 7 Rayner Nigel W 3 7 Timpson Nicolas J 3 46 Zeggini Eleftheria 3 7 McCarthy Mark I 3 7, Tuberculosis (Gambia): Newport Melanie 47 Sirugo Giorgio 47, (Oxford): Lyons Emily 3 Vannberg Fredrik 3 Hill Adrian VS 3, Ankylosing Spondylitis: Bradbury Linda A 48 Farrar Claire 49 Pointon Jennifer J 49 Wordsworth Paul 49 Brown Matthew A 48 49, Autoimmune Thyroid Disease: Franklyn Jayne A 50 Heward Joanne M 50 Simmonds Matthew J 50 Gough Stephen CL 50, Breast Cancer: Seal Sheila 51, Breast Cancer Susceptibility Collaboration (UK)*, Stratton Michael R 51 52 Rahman Nazneen 51, Multiple Sclerosis: Ban Maria 53 Goris An 53 Sawcer Stephen J 53 Compston Alastair 53, Gambian Controls (Gambia): Conway David 47 Jallow Muminatou 47 Newport Melanie 47 Sirugo Giorgio 47, (Oxford): Rockett Kirk A 3 Kwiatkowski Dominic P 3 5, (Cambridge): Leung Hin-Tak 2 Nutland Sarah 2 Stevens Helen E 2 Walker Neil M 2 Todd John A 2, Statistics (Cambridge): Easton Doug 12 Clayton David G 2, (Leicester): Burton Paul R 1 Tobin Martin D 1, (Oxford): Barrett Jeffrey C 3 Evans David M davide@ well. ox. ac. uk 3 c Morris Andrew P 3 Cardon Lon R lcardon@ fhcrc. org 3 55 e, (Oxford): Cardin Niall J 11 Davison Dan 11 Ferreira Teresa 11 Pereira-Gale Joanne 11 Hallgrimsdóttir Ingeleif B 11 Howie Bryan N 11 Marchini Jonathan L 11 Spencer Chris CA 11 Su Zhan 11 Teo Yik Ying 3 11 Vukcevic Damjan 11 Donnelly Peter 11, AITD Replication Group: Mitchell Sarah L 50 Newby Paul R 50 Brand Oliver J 50 Carr-Smith Jackie 50 Pearce Simon HS 56 Gough Stephen CL 50, IL23R replication: McGinnis R 5 Keniry A 5 Deloukas P 5, John D Reveille, Xiaodong Zhou, Linda A Bradbury, Anne-Marie Sims, Alison Dowling, Jacqueline Taylor, Tracy Doan, Lon R Cardon, John C Davis, Jennifer J Pointon, Laurie Savage, Michael M Ward, Thomas L Learch, Michael H Weisman, Paul Wordsworth, Matthew A Brown
Publication date
2007/11
Journal
Nature genetics
Volume
39
Issue
11
Pages
1329-1337
Publisher
Nature Publishing Group US
Description
We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major histocompatibility complex (MHC) tag SNPs from 1,000 independent cases of ankylosing spondylitis (AS), autoimmune thyroid disease (AITD), multiple sclerosis (MS) and breast cancer (BC). Comparing these data against a common control dataset derived from 1,500 randomly selected healthy British individuals, we report initial association and independent replication in a North American sample of two new loci related to ankylosing spondylitis, ARTS1 and IL23R, and confirmation of the previously reported association of AITD with TSHR and FCRL3. These findings, enabled in part by increased statistical power resulting from the expansion of the control reference group to include individuals from the other disease groups, highlight notable new possibilities for autoimmune regulation and suggest that IL23R may be a common …
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