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To compare directly the impact of glucagon‐like peptide‐1 secretion on glucose metabolism in individuals with Type 2 diabetes listed for Roux‐en‐Y gastric bypass surgery, randomized to be studied before and 7 days after undergoing Roux‐en‐Y gastric bypass or after following a very‐low‐calorie diet.

A semi‐solid meal test was used to investigate glucose, insulin and glucagon‐like peptide‐1 response. Insulin secretion in response to intravenous glucose and arginine stimulus was measured. Hepatic and pancreatic fat content was quantified using magnetic resonance imaging.

The decrease in fat mass was almost identical in the Roux‐en‐Y gastric bypass and the very‐low‐calorie diet groups (3.0±0.3 and 3.0±0.7kg). The early rise in plasma glucose level and in acute insulin secretion were greater after Roux‐en‐Y gastric bypass than after a very‐low‐calorie diet; however, the early …