Authors
Sarah Steven, Kieren G Hollingsworth, Peter K Small, Sean A Woodcock, Andrea Pucci, Benjamin Aribisala, Ahmad Al-Mrabeh, Ann K Daly, Rachel L Batterham, Roy Taylor
Publication date
2016/1/1
Journal
Diabetes care
Volume
39
Issue
1
Pages
158-165
Publisher
American Diabetes Association
Description
OBJECTIVE
This study determined whether the decrease in pancreatic triacylglycerol during weight loss in type 2 diabetes mellitus (T2DM) is simply reflective of whole-body fat or specific to diabetes and associated with the simultaneous recovery of insulin secretory function.
RESEARCH DESIGN AND METHODS
Individuals listed for gastric bypass surgery who had T2DM or normal glucose tolerance (NGT) matched for age, weight, and sex were studied before and 8 weeks after surgery. Pancreas and liver triacylglycerol were quantified using in-phase, out-of-phase MRI. Also measured were the first-phase insulin response to a stepped intravenous glucose infusion, hepatic insulin sensitivity, and glycemic and incretin responses to a semisolid test meal.
RESULTS
Weight loss after surgery was similar (NGT: 12.8 ± 0.8% and T2DM: 13.6 ± 0.7%) as was the …
Scholar articles
S Steven, KG Hollingsworth, PK Small, SA Woodcock… - Diabetes care, 2016