Authors
Jasper Kees Wim Gerritsen, Rania Mekary, Dana Pisică, Rosa Hanne Zwarthoed, John Laws Kilgallon, Noah Lee Nawabi, Charissa Alissa Cassandra Jessurun, Georges Versyck, Koen Pepijn Pruijn, Fleur Louise Fisher, Lien Solie, Alfred Kloet, Rishi Nandoe Tewarie, Joost Willem Schouten, Eelke Marijn Bos, Timothy Richard Smith, Clemens Maria Franciscus Dirven, Marike Lianne Daphne Broekman, Arnaud Jean Pierre Edouard Vincent, Steven De Vleeschouwer
Publication date
2024/6/1
Source
Journal of Clinical Oncology
Volume
42
Issue
16_suppl
Pages
e14017-e14017
Publisher
American Society of Clinical Oncology
Description
e14017
Background: Minimizing residual volume and preventing functional loss are the main goals in glioblastoma resections in eloquent areas. However, their combined impact on patient outcomes remains poorly understood. We therefore developed a novel onco-functional outcome (OFO) classification and evaluated its benefit in subgroups based on age, preoperative neurological morbidity (NIHSS), and Karnofsky Performance Score (KPS). Methods: Propensity-score matching was used to match OFO 1 (gross total resection, no functional loss) vs. OFO 2-3-4, OFO 2 (no gross total resection, no functional loss) vs. OFO 1-3-4, OFO 3 (gross total resection, functional loss) vs. OFO 1-2-4, and OFO 4 (no gross total resection, no functional loss) vs. OFO 1-2-3 for the overall cohort and subgroups. Cox proportional-hazard regressions and logistic regressions were performed to analyze the association between OFO …
Scholar articles
JKW Gerritsen, R Mekary, D Pisică, RH Zwarthoed… - 2024