Authors
Jasper Gerritsen, Rania Mekary, Dana Pisica, Rosa Zwarthoed, John Kilgallon, Noah Nawabi, Charissa Jessurun, Georges Versyck, Koen Pruijn, Fleur Fisher, Emma Larivière, Lien Solie, Alfred Kloet, Rishi Nandoe Tewarie, Joost Schouten, Eelke Bos, Timothy Smith, Clemens Dirven, Marike Broekman, Arnaud Vincent, Steven De Vleeschouwer
Publication date
2023/11/1
Journal
Neuro-Oncology
Volume
25
Issue
Supplement_5
Pages
v265-v265
Publisher
Oxford University Press
Description
BACKGROUND
Minimizing residual tumor volume and preventing functional loss are the primary goal in glioblastoma resections in eloquent areas. However, their combined impact on patient outcomes remains poorly understood. We therefore developed a novel onco-functional outcome (OFO) classification and evaluated its benefit in subgroups based on age, preoperative neurological morbidity (NIHSS), and preoperative Karnofsky Performance Score (KPS).
METHODS
Propensity-score matching was used to match OFO 1 (no residual volume, no postoperative functional loss) vs. non-OFO 1 patients for the overall cohort and subgroups based on age, NIHSS, and KPS. Cox proportional-hazard regressions were performed to analyze the association between OFO class and postoperative neurological deficits, KPS deterioration, receipt of adjuvant therapy, overall survival, and …
Scholar articles
J Gerritsen, R Mekary, D Pisica, R Zwarthoed… - Neuro-Oncology, 2023