Authors
Jasper KW Gerritsen, Rosa H Zwarthoed, John L Kilgallon, Noah Lee Nawabi, Georges Versyck, Charissa AC Jessurun, Koen P Pruijn, Fleur L Fisher, Emma Larivière, Lien Solie, Rania A Mekary, Djaina D Satoer, Joost W Schouten, Eelke M Bos, Alfred Kloet, Rishi Nandoe Tewarie, Timothy R Smith, Clemens MF Dirven, Steven De Vleeschouwer, Arnaud JPE Vincent, Marike LD Broekman
Publication date
2023/5/1
Journal
Neuro-oncology
Volume
25
Issue
5
Pages
958-972
Publisher
Oxford University Press
Description
Background
The impact of extent of resection (EOR), residual tumor volume (RTV), and gross-total resection (GTR) in glioblastoma subgroups is currently unknown. This study aimed to analyze their impact on patient subgroups in relation to neurological and functional outcomes.
Methods
Patients with tumor resection for eloquent glioblastoma between 2010 and 2020 at 4 tertiary centers were recruited from a cohort of 3919 patients.
Results
One thousand and forty-seven (1047) patients were included. Higher EOR and lower RTV were significantly associated with improved overall survival (OS) and progression-free survival (PFS) across all subgroups, but RTV was a stronger prognostic factor. GTR based on RTV improved median OS in the overall cohort (19.0 months, P < .0001), and in the subgroups with IDH wildtype tumors (18.5 months, P = .00055 …
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Scholar articles
JKW Gerritsen, RH Zwarthoed, JL Kilgallon, NL Nawabi… - Neuro-oncology, 2023