Authors
Jasper Gerritsen, Rosa Zwarthoed, John Kilgallon, Noah Nawabi, Charissa Jessurun, Georges Versyck, Koen Pruijn, Fleur Fisher, Emma Larivière, Lien Solie, Rania Mekary, Djaina Satoer, Joost Schouten, Eelke Bos, Fred Kloet, Rishi Nandoe Tewarie, Timothy R Smith, Clemens Dirven, Steven De Vleeschouwer, Marike Broekman, Arnaud Vincent
Publication date
2023/4/1
Journal
Neurosurgery
Volume
69
Issue
Supplement_1
Pages
50
Publisher
LWW
Description
METHODS:
Propensity-score matching with a 1: 3 ratio was used to match awake with asleep patients for the overall cohort and subgroups stratified by age, NIHSS score and KPS. Cox proportional-hazard regressions and multiple multivarible logistic regressions were performed to analyze the independent impact of awake mapping.
RESULTS:
1047 patients with resection for primary eloquent glioblastoma between 2010 and 2020 were included. Overall, awake craniotomy resulted in fewer neurological deficits at 3 months and 6 months postoperatively; a lower residual tumor volume, a higher extent of resection, longer overall survival and progression-free survival. Regression analyses independently associated awake craniotomy with gross-total resection and overall survival. Awake craniotomy led in all subgroups to a higher extent of resection and in the subgroups age< 70, NIHSS 0-1, NIHSS≥ 2 and KPS 90-100 …
Scholar articles
J Gerritsen, R Zwarthoed, J Kilgallon, N Nawabi… - Neurosurgery, 2023