Authors
Jasper KW Gerritsen, Rosa H Zwarthoed, John L Kilgallon, Noah L Nawabi, Charissa AC Jessurun, Georges Versyck, Koen P Pruijn, Fleur L Fisher, Emma Larivière, Lien Solie, Rania A Mekary, Djaina D Satoer, Joost W Schouten, Eelke M Bos, Alfred Kloet, Rishi Nandoe Tewarie, Timothy R Smith, Clemens MF Dirven, Steven De Vleeschouwer, Marike LD Broekman, Arnaud JPE Vincent
Publication date
2022/6/1
Journal
The Lancet Oncology
Volume
23
Issue
6
Pages
802-817
Publisher
Elsevier
Description
Background
Awake mapping has been associated with decreased neurological deficits and increased extent of resection in eloquent glioma resections. However, its effect within clinically relevant glioblastoma subgroups remains poorly understood. We aimed to assess the benefit of this technique in subgroups of patients with glioblastomas based on age, preoperative neurological morbidity, and Karnofsky Performance Score (KPS).
Methods
In this propensity score-matched analysis of an international, multicentre, cohort study (GLIOMAP), patients were recruited at four tertiary centres in Europe (Erasmus MC, Rotterdam and Haaglanden MC, The Hague, Netherlands, and UZ Leuven, Leuven, Belgium) and the USA (Brigham and Women's Hospital, Boston, MA). Patients were eligible if they were aged 18–90 years, undergoing resection, had a histopathological diagnosis of primary glioblastoma, their tumour was in …
Total citations
Scholar articles
JKW Gerritsen, RH Zwarthoed, JL Kilgallon, NL Nawabi… - The Lancet Oncology, 2022