Authors
Karsten Witt, Christine Daniels, Julia Reiff, Paul Krack, Jens Volkmann, Markus O Pinsker, Martin Krause, Volker Tronnier, Manja Kloss, Alfons Schnitzler, Lars Wojtecki, Kai Bötzel, Adrian Danek, Rüdiger Hilker, Volker Sturm, Andreas Kupsch, Elfriede Karner, Günther Deuschl
Publication date
2008/7/1
Journal
The Lancet Neurology
Volume
7
Issue
7
Pages
605-614
Publisher
Elsevier
Description
Background
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) reduces motor symptoms in patients with Parkinson's disease (PD) and improves their quality of life; however, the effect of DBS on cognitive functions and its psychiatric side-effects are still controversial. To assess the neuropsychiatric consequences of DBS in patients with PD we did an ancillary protocol as part of a randomised study that compared DBS with the best medical treatment.
Methods
156 patients with advanced Parkinson's disease and motor fluctuations were randomly assigned to have DBS of the STN or the best medical treatment for PD according to the German Society of Neurology guidelines. 123 patients had neuropsychological and psychiatric examinations to assess the changes between baseline and after 6 months. The primary outcome was the comparison of the effect of DBS with the best medical treatment on overall …
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Scholar articles
K Witt, C Daniels, J Reiff, P Krack, J Volkmann… - The Lancet Neurology, 2008