Authors
Martin M Reich, Andreas Horn, Florian Lange, Jonas Roothans, Steffen Paschen, Joachim Runge, Fritz Wodarg, Nicolo G Pozzi, Karsten Witt, Robert C Nickl, Louis Soussand, Siobhan Ewert, Virgina Maltese, Matthias Wittstock, Gerd-Helge Schneider, Volker Coenen, Philipp Mahlknecht, Werner Poewe, Wilhelm Eisner, Ann-Kristin Helmers, Cordula Matthies, Volker Sturm, Ioannis U Isaias, Joachim K Krauss, Andrea A Kühn, Günther Deuschl, Jens Volkmann
Publication date
2019/5/1
Journal
Brain
Volume
142
Issue
5
Pages
1386-1398
Publisher
Oxford University Press
Description
Deep brain stimulation of the internal globus pallidus is a highly effective and established therapy for primary generalized and cervical dystonia, but therapeutic success is compromised by a non-responder rate of up to 25%, even in carefully-selected groups. Variability in electrode placement and inappropriate stimulation settings may account for a large proportion of this outcome variability. Here, we present probabilistic mapping data on a large cohort of patients collected from several European centres to resolve the optimal stimulation volume within the pallidal region. A total of 105 dystonia patients with pallidal deep brain stimulation were enrolled and 87 datasets (43 with cervical dystonia and 44 with generalized dystonia) were included into the subsequent ‘normative brain’ analysis. The average improvement of dystonia motor score was 50.5 ± 30.9% in cervical and 58.2 ± 48.8% in generalized dystonia …
Scholar articles
MM Reich, A Horn, F Lange, J Roothans, S Paschen… - Brain, 2019